Found 1469 Hypotheses across 147 Pages (0.009 seconds)
  1. The frequency of G6PD deficiency is positively correlated with pathogen load index (402).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  2. Population density will be positively associated with G6PD deficiency (402).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 3 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  3. The frequency of the LCT*-13910T allele is higher in populations for which milking (dairy animal husbandry) is common (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  4. The frequency of the APOE e4 allele is higher in populations for which hunting and gathering is typical (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  5. The frequency of the APOE e4 allele is lower in populations for which agriculture is typical (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  6. The frequency of G6PD deficiency is positively associated with the level of development of food storage technologies (403).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  7. High lactose digestive capacity among adults evolved in populations that kept livestock (615).Holden, Clare - Phylogenetic analysis of the evolution of lactose digestion in adults, 1997 - 2 Variables

    The ability of adults to digest lactose is common only in populations of European and circum-Mediterranean origin, a distribution thought to be a result of genetic adaptation to drinking milk from domestic livestock. Two additional hypotheses have been proposed to explain the distribution of high lactose digestion capacity: (1) supplemental calcium in high-latitude populations prone to vitamin D deficiency and (2) maintenance of water and electrolytes in the body in highly arid environments. However, these hypotheses are confounded by the shared ancestry of populations whose lactose digestion capability has been tested. Therefore, the authors test all three hypotheses using a phylogenetic comparative method for 62 cultures.

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  8. Pastoralism is always adopted prior to the development of high lactose digestion capacity among adults (615).Holden, Clare - Phylogenetic analysis of the evolution of lactose digestion in adults, 1997 - 2 Variables

    The ability of adults to digest lactose is common only in populations of European and circum-Mediterranean origin, a distribution thought to be a result of genetic adaptation to drinking milk from domestic livestock. Two additional hypotheses have been proposed to explain the distribution of high lactose digestion capacity: (1) supplemental calcium in high-latitude populations prone to vitamin D deficiency and (2) maintenance of water and electrolytes in the body in highly arid environments. However, these hypotheses are confounded by the shared ancestry of populations whose lactose digestion capability has been tested. Therefore, the authors test all three hypotheses using a phylogenetic comparative method for 62 cultures.

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  9. Population level variation in DRD4 alleles is attributable to general bottleneck effects that also acted on non-DRD4 genes (317).Chen, Chuansheng - Population migration and the variation of dopamine D4 receptor (DRD4) allele..., 1999 - 2 Variables

    Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

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  10. There is positive selection for high lactose digestion capacity among adults in populations living in drier environments (615).Holden, Clare - Phylogenetic analysis of the evolution of lactose digestion in adults, 1997 - 2 Variables

    The ability of adults to digest lactose is common only in populations of European and circum-Mediterranean origin, a distribution thought to be a result of genetic adaptation to drinking milk from domestic livestock. Two additional hypotheses have been proposed to explain the distribution of high lactose digestion capacity: (1) supplemental calcium in high-latitude populations prone to vitamin D deficiency and (2) maintenance of water and electrolytes in the body in highly arid environments. However, these hypotheses are confounded by the shared ancestry of populations whose lactose digestion capability has been tested. Therefore, the authors test all three hypotheses using a phylogenetic comparative method for 62 cultures.

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