Found 2184 Hypotheses across 219 Pages (0.007 seconds)
  1. Populations which have remained near their origin will show a lower proportion of long alleles of DRD4 than those that migrated further away (312).Chen, Chuansheng - Population migration and the variation of dopamine D4 receptor (DRD4) allele..., 1999 - 2 Variables

    Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

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  2. Within each region, societies with the lowest percentage of long DRD4 alleles will tend to be sedentary, while societies with the highest percentage of long DRD4 alleles will tend to be nomadic (313-314).Chen, Chuansheng - Population migration and the variation of dopamine D4 receptor (DRD4) allele..., 1999 - 2 Variables

    Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

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  3. Population-level variation in DRD4 alleles is a result of the distributions of DRD4 alleles in founder groups (317).Chen, Chuansheng - Population migration and the variation of dopamine D4 receptor (DRD4) allele..., 1999 - 2 Variables

    Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

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  4. Migratory distance from East Africa will be positively associated with between-population DRD4 exon III expected heterozygosity (2).Gören, Erkan - The biogeographic origins of novelty-seeking traits, 2016 - 2 Variables

    The researcher looks for empirical evidence of natural selection as an explanation for worldwide variation in novelty-seeking behavior. Examining the relationship between variability in frequency of the DRD4 exon III 7-repeat allele variant (a variant theorized to stifle dopamine reception and thus encourage compensatory novelty-seeking behavior) and migratory distance from prehistoric humans' origin point in East Africa yields a positive correlation. After controlling for various biogeographic indicators, the researcher theorizes that presence of the DRD4 exon III 7-repeat variant provided an exploratory urge and evolutionary advantage to hunter-gatherers and pastoralists who migrated into unfamiliar environments.

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  5. Population density will be positively associated with G6PD deficiency (402).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 3 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  6. The frequency of G6PD deficiency is positively correlated with pathogen load index (402).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  7. The frequency of the LCT*-13910T allele is higher in populations for which milking (dairy animal husbandry) is common (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  8. There is no correlation between the frequency of the LCT*-13910T allele and populations for which cattle breeding is common (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  9. The frequency of the APOE e4 allele is higher in populations for which hunting and gathering is typical (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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  10. The frequency of the APOE e4 allele is lower in populations for which agriculture is typical (401).Borinskaya, S. A. - Combination of Genetic and Humanitarian (Cross-Cultural) Methods for the Ide..., 2015 - 2 Variables

    Researchers used population samples from the ALFRED database and the Human Genome Diversity Project (HGDP), in conjunction with 68 populations from the Ethnographic Atlas, in an attempt to identify specific genes involved in human adaptation to environmental stimuli as a result of migration. Specifically, researchers looked at the allele frequencies for four different genes typically associated with varying subsistence forms. These four included the APOE apolipoprotein E gene (lipid transport and regulation of cholesterol), LCT lactase gene (enzyme that decomposes lactose), CCR5 chemokine receptor gene (deletion mutation that decreases immunodeficiency virus propagation), and the ADH1B alcohol dehydrogenase gene (important enzyme for alcohol metabolism). The allele frequencies were then analyzed to distinguish any possible correlation to economic-culture types using a two-sided Spearman Test. Researchers also ran a similar test to analyze allele frequencies and pathogen load, however the majority of the findings were not statistically significant. The findings suggest that there is a definite relationship between the allele frequencies and type of economy of a population.

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