Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe

Chen, Chuansheng; Burton, Michael L.; Greenberger, Ellen; Dmitrieva, Julia

Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe

Evolution and Human Behavior • Vol/Iss. 20(5) • Elsevier • • Published In 1999 • Pages: 309-324 •

By Chen, Chuansheng, Burton, Michael L., Greenberger, Ellen, Dmitrieva, Julia

Abstract

Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

Samples
Sample Used	Coded Data	Comment
Ethnographic Atlas (EA)	Other researchers

Hypotheses (4)
Hypothesis	Supported
Populations which have remained near their origin will show a lower proportion of long alleles of DRD4 than those that migrated further away (312).	Supported
Within each region, societies with the lowest percentage of long DRD4 alleles will tend to be sedentary, while societies with the highest percentage of long DRD4 alleles will tend to be nomadic (313-314).	Some support
Population level variation in DRD4 alleles is attributable to general bottleneck effects that also acted on non-DRD4 genes (317).	Not Supported
Population-level variation in DRD4 alleles is a result of the distributions of DRD4 alleles in founder groups (317).	Not Supported

Documents and Hypotheses Filed By: erik.ringen

Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe

Evolution and Human Behavior • Vol/Iss. 20(5) • Elsevier • • Published In 1999 • Pages: 309-324 • Cite

By Chen, Chuansheng, Burton, Michael L., Greenberger, Ellen, Dmitrieva, Julia

Abstract

Samples

Hypotheses (4)

Evolution and Human Behavior • Vol/Iss. 20(5) • Elsevier • • Published In 1999 • Pages: 309-324 •