Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe

Evolution and Human Behavior Vol/Iss. 20(5) Elsevier Published In Pages: 309-324
By Chen, Chuansheng, Burton, Michael L., Greenberger, Ellen, Dmitrieva, Julia


Dopamine receptor D4 (DRD4) exhibits the largest number of polymorphisms of any dopamine receptor yet identified, and variation in DRD4 has been linked to variation in traits such as novelty-seeking and attention deficit/hyperactivity disorder. DRD4 also exhibits large variation between populations. Here, the authors test the hypothesis that natural selection acting on DRD4 may account for variation in between-population migratory patterns, using genetic and historical data from 39 populations.

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